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A comparative study of two dosage levels of ibuprofen syrup in children with pyrexia
Insights
Ibuprofen syrup effectively reduced fever in children. The higher dose (30 mg/kg) showed greater effectiveness than the lower dose (20 mg/kg) over 24 hours, with no reported side effects.
Area of Science:
- Pediatrics
- Pharmacology
Background:
- Fever is a common symptom in children.
- Effective antipyretic medications are crucial for pediatric care.
Purpose of the Study:
- To evaluate the antipyretic efficacy of two ibuprofen syrup dosages in children.
- To compare the effectiveness and safety of 20 mg/kg versus 30 mg/kg ibuprofen.
Main Methods:
- A randomized trial involving 50 children with fever.
- Children received either 20 mg/kg or 30 mg/kg of ibuprofen syrup.
- Rectal temperatures were monitored over a 24-hour period.
Main Results:
- Both ibuprofen dosages significantly reduced rectal temperatures (p < 0.001).
- The higher dose (30 mg/kg) demonstrated a statistically significant advantage at 12 and 20 hours (p < 0.05).
- No adverse side effects were reported for either dosage.
Conclusions:
- Ibuprofen syrup is an effective antipyretic agent in pediatric populations.
- The higher dosage (30 mg/kg) is preferable due to enhanced efficacy.
- Ibuprofen syrup was well-tolerated and palatable in this study cohort.
Abstract:
In a study of the antipyretic effect of two dosage levels of ibuprofen syrup in children with fever due to a variety of causes, forty-four out of the fifty children admitted completed the 24-hour trial period, twenty-three receiving 20 mg ibuprofen/kg body-weight, twenty-one receiving 30 mg/kg ibuprofen. Both dosage levels gave highly significant (p less than 0.001) reductions in rectal temperatures, with a statistically significant reduction, at the 5% level, in favour of the higher dose at 12 and 20 hours. No side-effects were reported at either dosage level, and the taste was acceptable to all the children. It is concluded that ibuprofen was a useful and effective antipyretic drug in the population studied, and that the higher dosage is preferable to the lower, being more effective, equally palatable, and giving rise to no side-effects in this study.