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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Updated: Jun 23, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Scleroderma and scleroderma-like syndromes.

Katarzyna Romanowska-Próchnicka1, Martyna Dziewit1, Aleksandra Lesiak2

  • 1Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Frontiers in Immunology
|June 18, 2024
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis involves progressive fibrosis. Scleroderma-like syndromes mimic this condition but stem from diverse causes like autoimmune disorders, genetics, or toxins, requiring distinct diagnosis and management.

Keywords:
geneticmorpheasclerodermascleroderma-like syndromessyndromes of inflammatory/autoimmunesystemic sclerosistoxic

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Area of Science:

  • Rheumatology
  • Dermatology
  • Internal Medicine

Background:

  • Systemic sclerosis is a fibrotic connective tissue disease affecting skin and internal organs.
  • Cutaneous sclerosis can also result from other conditions, termed scleroderma-like syndromes.
  • These syndromes share clinical features with systemic sclerosis but have varied etiologies.

Purpose of the Study:

  • To review the literature on scleroderma-like syndromes.
  • To differentiate these syndromes from systemic sclerosis.
  • To outline their predisposing factors, pathogenesis, clinical presentation, diagnosis, and treatment.

Main Methods:

  • Literature review of scleroderma-like syndromes.
  • Analysis of etiological categories: inflammatory/autoimmune, genetic, metabolic, toxic, drug-induced, occupational, paraneoplastic, and deposition disorders.
  • Comparative analysis with systemic sclerosis.

Main Results:

  • Scleroderma-like syndromes encompass a broad range of conditions mimicking systemic sclerosis.
  • Etiologies are diverse, including autoimmune, genetic, metabolic, toxic, drug-induced, occupational, paraneoplastic, and deposition disorders.
  • Each syndrome presents unique diagnostic and therapeutic challenges distinct from systemic sclerosis.

Conclusions:

  • Accurate differentiation of scleroderma-like syndromes from systemic sclerosis is crucial for appropriate patient management.
  • Understanding the diverse etiologies is key to targeted diagnosis and treatment.
  • Further research into specific scleroderma-like syndromes can improve clinical outcomes.