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Related Experiment Videos

Long-range implications for the mother. The Aberdeen experience.

J M Stowers, H W Sutherland, D F Kerridge

    Diabetes
    |June 1, 1985
    PubMed
    Summary

    Women with post-pregnancy impaired glucose tolerance (IGT) showed sustained abnormal glucose levels in about 35% after 12.9 years. Diet alone was as effective as chlorpropamide, with age and fasting glucose predicting IGT progression.

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    Maternal glucose response to a standardized test meal throughout pregnancy and postnatally.

    American journal of obstetrics and gynecology·1994

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Women's Health

    Background:

    • Post-pregnancy impaired glucose tolerance (IGT) is a risk factor for future diabetes.
    • Long-term outcomes and effective management strategies for IGT require further investigation.

    Purpose of the Study:

    • To assess the long-term glucose tolerance in women diagnosed with IGT after pregnancy.
    • To compare the efficacy of chlorpropamide versus diet alone in managing IGT.
    • To identify factors associated with the progression of IGT.

    Main Methods:

    • A longitudinal follow-up study of 112 women with post-pregnancy IGT diagnosed via intravenous glucose tolerance test (IVGTT).
    • Participants were treated with either chlorpropamide or diet only.
    • Assessment included IVGTT, fasting plasma glucose (FPG), and islet cell antibody (ICA) testing over up to 22 years.

    Main Results:

    • After a mean follow-up of 12.9 years, 35% of women had abnormal IVGTT, and less than 7% had overt diabetes.
    • Chlorpropamide showed no significant benefit over diet alone.
    • Factors associated with worsening glucose tolerance included older age at diagnosis/follow-up and higher initial FPG (≥5.8 mM).
    • Obesity was linked to increased vascular complications but not directly to glucose tolerance deterioration.
    • ICA were weakly positive in 12.5% of subjects and did not correlate with glucose tolerance outcomes.

    Conclusions:

    • Dietary management appears crucial for long-term glucose tolerance in women with post-pregnancy IGT.
    • Age and initial FPG are key predictors of IGT progression.
    • The prevalence of IGT and diabetes was lower in this cohort compared to others, potentially due to sustained dietary interventions.

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