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Updated: Jun 23, 2025

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Association between gut microbiota and acute pancreatitis: a bidirectional Mendelian randomization study
Feng Zhou1, Yang Liu1, Yanqing Shi2
1Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Gut microbiota dysbiosis is linked to acute pancreatitis. Specific bacteria like Bacteroidales increase risk, while Prevotella and Ruminiclostridium offer protection, suggesting microbiota modulation for pancreatitis treatment.
Area of Science:
- Gastroenterology and Microbiology
- Human Genetics
Background:
- Gut microbiota dysbiosis is implicated in acute pancreatitis.
- The precise relationship between host microbiota and pancreatic disease requires clarification.
Purpose of the Study:
- To investigate the bidirectional association between gut microbiota and acute pancreatitis using Mendelian randomization (MR).
Main Methods:
- Utilized genome-wide association studies (GWAS) summary statistics for gut microbiota and acute pancreatitis.
- Employed a two-sample bidirectional MR design with sensitivity analyses to confirm results.
Main Results:
- Identified seven microbiota taxa associated with pancreatitis risk.
- Bacteroidales and Bacteroidia (host genetic-driven) correlate with increased pancreatitis risk.
- Coprococcus and Eubacterium fissicatena group show positive association; Prevotella, Ruminiclostridium, and Ruminococcaceae show protective effects.
Conclusions:
- Bidirectional relationship highlights host-microbiota crosstalk in acute pancreatitis pathogenesis.
- Targeted modulation of gut microbiota may offer a strategy for preventing and treating acute pancreatitis.
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