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Sleep-disordered breathing on respiratory polygraphy in neonates with spina bifida

Lorine Wachsmuth1, Christian Bieli2, Patrice Grehten3,4

  • 1Division of Intensive Care and Neonatology, University Children's Hospital Zurich, Zurich, Switzerland.

Pediatric Pulmonology
|June 18, 2024
PubMed

Insights

Routine respiratory polygraphy (RPG) testing in neonates with spina bifida is recommended to identify sleep-disordered breathing (SDB). Early detection and treatment with caffeine therapy significantly improve SDB in these infants.

Area of Science:

  • Pediatric Pulmonology
  • Neonatal Medicine
  • Sleep Medicine

Background:

  • Sleep-disordered breathing (SDB) is prevalent in children with spina bifida, yet international standards for neonatal screening are lacking.
  • Few studies have investigated SDB specifically in neonates with spina bifida.

Purpose of the Study:

  • To determine the indication for routine respiratory polygraphy (RPG) in neonates with spina bifida.
  • To assess the therapeutic consequences of early SDB detection and treatment.

Main Methods:

  • Retrospective cohort study of neonates with spina bifida undergoing RPG during hospitalization.
  • Evaluation of baseline and 3-month follow-up RPG by experienced pediatric pulmonologists.
  • Division of cohort based on RPG results and recommendations for caffeine therapy.

Main Results:

  • 48 neonates with spina bifida underwent RPG.
  • 45.8% of neonates showed central SDB, leading to caffeine therapy.
  • Follow-up RPG at 3 months indicated significant SDB improvement, reducing the need for continued caffeine.

Conclusions:

  • Routine RPG testing is indicated for neonates with spina bifida.
  • Early detection of SDB facilitates targeted treatment, improving outcomes.
  • Implementation of routine RPG can enhance SDB management in this population.
Abstract

Keywords:
caffeine therapymyelomeningoceleneonatesrespiratory polygraphysleep apneasleep‐disordered breathingspina bifida

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