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Asiaticoside Inhibits Growth and Metastasis in Non-Small Cell Lung Cancer by Disrupting EMT via Wnt/β-Catenin Pathway

Yanan Zhang1, Jiangyong Liu2, Gang Yang3

  • 1Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Environmental Toxicology
|June 18, 2024
PubMed

Insights

Asiaticoside (ATS) inhibits non-small cell lung cancer (NSCLC) growth and metastasis. This natural compound blocks epithelial-mesenchymal transition (EMT) by suppressing Wnt/β-catenin signaling, offering a potential therapeutic strategy for NSCLC.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality globally.
  • Asiaticoside (ATS), a triterpenoid saponin, exhibits antitumor properties, but its role in NSCLC is not fully understood.

Purpose of the Study:

  • To investigate the anti-cancer effects and underlying mechanisms of Asiaticoside (ATS) in non-small cell lung cancer (NSCLC).

Main Methods:

  • In vitro studies on NSCLC cell lines assessing proliferation, cell cycle, migration, and invasiveness.
  • Western blotting for protein expression analysis.
  • In vivo xenograft mouse model to evaluate tumorigenesis.

Main Results:

  • ATS significantly inhibited NSCLC cell proliferation, migration, and invasion.
  • ATS reversed TGF-β-induced epithelial-mesenchymal transition (EMT) and suppressed Wnt/β-catenin signaling.
  • Restoring β-catenin diminished the anti-cancer effects of ATS.
  • ATS repressed tumor growth in vivo.

Conclusions:

  • Asiaticoside (ATS) demonstrates significant anti-tumor and anti-metastatic potential in NSCLC.
  • ATS functions by inhibiting EMT through the Wnt/β-catenin signaling pathway.
  • ATS represents a promising therapeutic agent for NSCLC treatment.
Keywords:
NSCLCasiaticosidemotionproliferationβ‐catenin

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