Does Managing Patients With Chronic Rhinosinusitis Improve Their Depression Score? Prospective Study.

Area of Science:

• Otolaryngology
• Psychiatry
• Clinical Research

Background:

• Chronic rhinosinusitis (CRS) is associated with a significant burden on patients' quality of life.
• Assessing the prevalence of depression in CRS patients is crucial for comprehensive care.
• Understanding the impact of treatment on psychological well-being is essential.

Purpose of the Study:

• To determine the risk of depression in patients diagnosed with chronic rhinosinusitis.
• To evaluate the effectiveness of medical and surgical treatments on depression scores in CRS patients.
• To explore the correlation between sinonasal symptom severity and depression levels.

Main Methods:

• A prospective cohort study involving 38 adult CRS patients (≥14 years) was conducted.
• Validated instruments, Sinonasal Outcome Test (SNOT-22) and Patient Health Questionnaire-9 (PHQ-9), were used pre- and post-treatment.
• Statistical analyses included Spearman's correlation and simple linear regression to assess score changes and relationships.

Main Results:

• 15.7% of participants exhibited scores indicative of major depressive disorder (PHQ-9 ≥10).
• Significant improvements were observed in both PHQ-9 (mean change -2.7) and SNOT-22 (mean change -24.9) scores post-treatment (P < .001).
• A positive correlation was found between SNOT-22 and PHQ-9 scores (r=0.522, P < .001), with changes in SNOT-22 significantly predicting changes in PHQ-9 (β=0.178, P < .0001).

Conclusions:

• Chronic rhinosinusitis negatively affects patients' psychological well-being and quality of life.
• Comprehensive, patient-centered care, incorporating maximal medical and surgical treatments, is vital for mitigating the adverse effects of CRS.
• Treatment interventions demonstrably improve both sinonasal symptoms and depressive symptoms in CRS patients.