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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Immune checkpoint inhibitor use in head and neck squamous cell carcinoma: the current landscape and future

Elinor R Gatfield1, John Tadross2,3,4, William Ince1

  • 1Oncology Centre, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Future Oncology (London, England)
|June 18, 2024
PubMed

Insights

Immune checkpoint inhibitors show promise for head and neck squamous cell carcinoma. This review examines their use across all disease stages, including curative and metastatic settings.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Immune checkpoint inhibitors (ICIs) are approved for advanced head and neck squamous cell carcinoma (HNSCC).
  • Ongoing research explores ICIs in earlier stages and combined therapies for HNSCC.

Purpose of the Study:

  • To review the current evidence for ICI use in all stages of HNSCC.
  • To discuss future directions for ICI application in HNSCC management.

Main Methods:

  • Systematic literature review of published trials.
  • Analysis of ongoing clinical trials assessing ICI efficacy.
  • Evaluation of ICI use in curative and metastatic settings.

Main Results:

  • ICIs are established in unresectable, recurrent, or metastatic HNSCC.
  • Evidence is accumulating for ICI use in concomitant, neoadjuvant, and adjuvant HNSCC treatment.
  • Multimodality approaches incorporating ICIs are being investigated for metastatic HNSCC.

Conclusions:

  • Immune checkpoint inhibitors represent a significant advancement in HNSCC treatment.
  • Further research is needed to optimize ICI integration into curative and advanced HNSCC care.
  • Future strategies will likely involve novel combinations and earlier administration of ICIs.
Keywords:
head and neck squamous cell carcinomaimmune checkpoint inhibitorsimmunotherapy

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