Association between TyG index and long-term prognosis of patients with ST-segment elevated myocardial infarction
Deli Zeng1, Kai Wang1, Zijun Chen1
1Department of Cardiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Insights
The triglyceride-glucose (TyG) index is linked to higher all-cause mortality risk in ST-segment elevated myocardial infarction (STEMI) patients post-PCI. Higher TyG index values indicate a significantly increased risk of death over 3 years.
Area of Science:
- Cardiology
- Metabolic Syndrome Research
- Clinical Outcomes
Background:
- ST-segment elevated myocardial infarction (STEMI) is a critical cardiovascular event.
- Identifying reliable predictors of mortality post-STEMI is crucial for patient management.
- The triglyceride-glucose (TyG) index is emerging as a marker for metabolic dysfunction.
Purpose of the Study:
- To investigate the association between the serum triglyceride-glucose (TyG) index and all-cause mortality in STEMI patients.
- To determine if the TyG index can serve as an independent predictor of long-term mortality after percutaneous coronary intervention (PCI).
Main Methods:
- A retrospective study of 896 STEMI patients who underwent PCI.
- Patients were stratified into quartiles based on TyG index values.
- All-cause mortality was assessed over a median follow-up of 3 years, with adjustments for multiple clinical factors.
Main Results:
- The TyG index was independently associated with increased all-cause mortality (OR, 1.39).
- Higher quartiles of the TyG index showed a dose-response relationship with mortality risk (Q4 OR, 4.02).
- Each unit increase in TyG index correlated with a 68% increase in multivariate risk for all-cause mortality.
Conclusions:
- The TyG index is significantly associated with long-term all-cause mortality in STEMI patients undergoing PCI.
- The TyG index may be a valuable prognostic biomarker in this patient population.
- An interaction between LDL-c and the TyG index was observed, suggesting complex risk modulation.
Objective:
To assess the association between the serum triglyceride-glucose product index (TyG index) and the risk for all-cause mortality in patients with ST-segment elevated myocardial infarction (STEMI).
Design:
Retrospective.
Setting And Participants:
This retrospective study included 896 patients with STEMI who underwent percutaneous coronary intervention (PCI) at a comprehensive university-affiliated hospital between January 2016 and January 2019.
Methods:
Patients were equally divided into quartiles (Q1, Q2, Q3 and Q4 group) according to TyG index values.
Primary Endpoint:
All-cause mortality.
Results:
After a median follow-up of 3 years, 108 (17.1%) patients died. TyG index was independently associated with increased all-cause mortality (OR, 1.39; 95% CI, 1.22 to 1.58) after adjusting for age, sex, low-density lipoprotein cholesterol (LDL-c), cardiac troponin I, B-type natriuretic peptide, delayed PCI, post-PCI complications, medication and left ventricular ejection fraction. The adjusted OR was 1.31 (95% CI, 0.62 to 2.77) for Q2, 2.12 (95% CI, 1.01 to 4.53) for Q3 and 4.02 (95% CI, 1.90 to 8.78) for Q4 compared with the lowest quartile (Q1) (p for trend<0.001). In the restricted cubic spline regression model, the relationship between the TyG index and the risk of all-cause mortality was linear (p for non-linear=0.575). Each unit increase in the TyG index was associated with a 68% increase in the multivariate risk for all-cause mortality (OR 1.68; 95% CI, 1.20 to 2.38). In the subgroup analysis, there was an interaction between LDL-c and the TyG index on the risk of all-cause mortality (p for interaction=0.007).
Conclusion:
The TyG index was significantly associated with the long-term all-cause mortality among patients with STEMI who underwent PCI.
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