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Correlation between cognitive changes and neuroradiological changes over time in multiple sclerosis: a systematic
Leila Simani1, Leila Molaeipour2, Saeid Kian3
1Cognitive Neuroscience Division, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Journal of Neurology
|June 18, 2024
Summary
Longitudinal studies reveal cognitive changes in multiple sclerosis (MS) are linked to MRI-detected brain changes. Specifically, Symbol Digit Modalities Test (SDMT)/Paced Auditory Serial Addition Test (PASAT) and verbal fluency correlate with T2 lesion volume and atrophy.
Area of Science:
- Neuroimaging and Cognitive Science
- Neurology and Clinical Research
Background:
- Longitudinal studies on neuroimaging and cognitive changes in multiple sclerosis (MS) are scarce.
- Understanding the relationship between neuroradiological and cognitive changes in MS requires systematic review.
Approach:
- Conducted a systematic literature search until August 2023 to identify relevant studies.
- Included studies examining relationships between MRI metrics (T2LV, WML, GMV) and cognitive tests (SDMT, PASAT, verbal fluency).
- Performed a meta-analysis on eligible studies to quantify associations.
Key Points:
- 35 studies were identified exploring MRI changes and cognitive outcomes in MS.
- Meta-analysis revealed significant correlations between SDMT/PASAT and grey matter volume (GMV).
- Verbal fluency showed a significant association with T2 lesion volume (T2LV).
Conclusions:
- Cognitive decline in MS, particularly in SDMT/PASAT performance and verbal fluency, is associated with T2LV and brain atrophy.
- Findings highlight the link between structural brain changes and cognitive function in MS.
- Further high-quality research is needed due to limitations in existing studies.
