The role of glucagon-like peptide-1/GLP-1R and autophagy in diabetic cardiovascular disease

Area of Science:

• Cardiovascular Biology
• Metabolic Diseases
• Cellular Homeostasis

Background:

• Diabetes mellitus significantly increases macrovascular and microvascular complications.
• Endothelial dysfunction is an early pathogenic event in diabetes-related vascular disease.
• Understanding molecular mechanisms is crucial for developing effective therapies.

Purpose of the Study:

• To review the role of the glucagon-like peptide (GLP)-1/GLP-1 receptor (GLP-1R) system in diabetic endothelial dysfunction.
• To explore the involvement of autophagy in the pathogenesis of diabetic vascular complications.
• To highlight the potential therapeutic crosstalk between autophagy and the GLP-1/GLP-1R axis.

Main Methods:

• Literature review focusing on molecular mechanisms.
• Analysis of studies on GLP-1/GLP-1R signaling in endothelial cells.
• Examination of research on autophagy's role in diabetic vascular pathology.

Main Results:

• The GLP-1/GLP-1R system is implicated in mitigating diabetic endothelial dysfunction.
• Autophagy plays a critical role in diabetes-induced vascular endothelium damage.
• A potential interplay exists between autophagy and the GLP-1/GLP-1R axis in managing diabetic angiopathy.

Conclusions:

• The GLP-1/GLP-1R axis and autophagy are key players in diabetic vascular complications.
• Targeting the crosstalk between autophagy and GLP-1/GLP-1R may offer novel therapeutic strategies for diabetic angiopathy.