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Updated: Jun 23, 2025
Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures
Published on: August 1, 2011
Neuronal avalanches in temporal lobe epilepsy as a noninvasive diagnostic tool investigating large scale brain
Marie-Constance Corsi1, Emahnuel Troisi Lopez2, Pierpaolo Sorrentino3,4
1Sorbonne Université, Institut du Cerveau - Paris Brain Institute -ICM, CNRS, Inria, Inserm, AP-HP, Hopital de la Pitié Salpêtrière, 75013, Paris, France. marie-constance.corsi@inria.fr.
Abstract:
The epilepsy diagnosis still represents a complex process, with misdiagnosis reaching 40%. We aimed at building an automatable workflow, helping the clinicians in the diagnosis of temporal lobe epilepsy (TLE). We hypothesized that neuronal avalanches (NA) represent a feature better encapsulating the rich brain dynamics compared to classically used functional connectivity measures (Imaginary Coherence; ImCoh). We analyzed large-scale activation bursts (NA) from source estimation of resting-state electroencephalography. Using a support vector machine, we reached a classification accuracy of TLE versus controls of 0.86 ± 0.08 (SD) and an area under the curve of 0.93 ± 0.07. The use of NA features increase by around 16% the accuracy of diagnosis prediction compared to ImCoh. Classification accuracy increased with larger signal duration, reaching a plateau at 5 min of recording. To summarize, NA represents an interpretable feature for an automated epilepsy identification, being related with intrinsic neuronal timescales of pathology-relevant regions.
