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Updated: Jun 23, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

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Published on: January 17, 2020

Atroposelective catalysis.

Tanno A Schmidt¹, Valeriia Hutskalova¹, Christof Sparr²

¹Department of Chemistry, University of Basel, Basel, Switzerland.

Nature Reviews. Chemistry

|June 18, 2024

Summary

This summary is machine-generated.

Atropisomeric compounds, stereoisomers with restricted rotation, are crucial in medicinal chemistry and catalysis. This review covers catalyst-controlled synthesis of atropisomers, including complex systems with multiple stereogenic axes.

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A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis

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Area of Science:

Organic Chemistry
Stereochemistry
Catalysis

Background:

Atropisomeric compounds, defined by restricted bond rotation, are gaining prominence.
Their applications span medicinal chemistry, catalysis, and molecular nanoscience.
Recent interest fuels advancements in molecular motors and drug discovery programs.

Purpose of the Study:

To review catalyst-controlled stereoselective synthesis of atropisomers.
To highlight recent advancements and explore underdeveloped atropisomeric scaffolds.
To discuss complex systems with multiple stereogenic axes and higher-order stereogenicity.

Main Methods:

Generalizing synthetic methodologies for atropisomer synthesis.
Categorizing methods into desymmetrizations, kinetic resolutions, cross-coupling, and de novo ring formations.
Focusing on catalyst-controlled stereoselective approaches.

Main Results:

A diverse set of synthetic methodologies is available for atropisomer synthesis.
Recent advancements have expanded the scope of atroposelective reactions.
The review emphasizes scaffolds beyond C(sp2)-C(sp2) axes and complex stereogenic systems.

Conclusions:

Catalyst-controlled synthesis is key to accessing diverse atropisomers.
Further research into underdeveloped scaffolds and complex systems is warranted.
Atropisomers hold significant potential for future applications in various scientific fields.