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Ventricular fibrillation.

B Surawicz

    Journal of the American College of Cardiology
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Sudden cardiac death is often caused by ventricular fibrillation, a condition linked to coronary artery disease. Understanding its electrophysiologic mechanisms, like reentry and automaticity, is key to prevention.

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    Area of Science:

    • Cardiology
    • Electrophysiology
    • Cardiac Arrhythmias

    Background:

    • Ventricular fibrillation is a primary cause of sudden cardiac death, particularly in patients with coronary artery disease.
    • Understanding the underlying electrophysiologic mechanisms is crucial for developing effective interventions.

    Purpose of the Study:

    • To review the electrophysiologic mechanisms of ventricular fibrillation.
    • To identify conditions that facilitate ventricular fibrillation.
    • To explore the origins of arrhythmia during acute myocardial ischemia.

    Main Methods:

    • Review of electrophysiologic mechanisms including automaticity, fiber transformation, injury currents, and reentry.
    • Identification of facilitating conditions such as bradycardia, long QT syndrome, and myocardial ischemia.

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  • Analysis of electrophysiologic studies during acute myocardial ischemia.

    • Main Results:

    • Electrophysiologic mechanisms of ventricular fibrillation involve automaticity, fiber transformation, injury currents, and reentry.
    • Facilitating factors include bradycardia, long QT syndrome, electrolyte imbalance, drugs, sympathetic stimulation, and myocardial ischemia.
    • Early arrhythmia activity during ischemia may originate from Purkinje fibers or the epicardial rim.

    Conclusions:

    • Reentrant arrhythmias in ischemic myocardium result from nonhomogeneous hyperkalemia and acidosis.
    • Further research into these mechanisms can inform strategies to prevent sudden cardiac death.