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[Keratoglobus].

Y Pouliquen, P Dhermy, M A Espinasse

    Journal Francais D'Ophtalmologie
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Keratoglobus is a rare bilateral corneal disease causing thinning and protrusion. This study details 5 cases, highlighting anatomical differences between congenital and acquired forms.

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    Area of Science:

    • Ophthalmology
    • Genetics
    • Pathology

    Background:

    • Keratoglobus is a bilateral corneal disease characterized by diffuse thinning and protrusion of the cornea.
    • It can lead to complications like corneal edema, perforation, and is often associated with systemic conditions.

    Observation:

    • This report presents 5 cases of keratoglobus, with 4 patients undergoing penetrating keratoplasty.
    • Congenital keratoglobus cases (3) consistently showed absent Bowman's membrane, disorganized stroma, and thickened Descemet's membrane with abnormalities.
    • Acquired keratoglobus (1 case) presented localized breaks in Bowman's membrane, similar to keratoconus.

    Findings:

    • Distinct anatomopathological differences exist between congenital and acquired forms of keratoglobus.
    • Congenital keratoglobus involves widespread structural anomalies of the cornea.

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  • Acquired keratoglobus may share some histopathological features with keratoconus.

    • Implications:

    • Understanding these differences is crucial for diagnosis and management of keratoglobus.
    • Corneal transplantation (penetrating keratoplasty) is a viable treatment option for severe cases.
    • Further research into the genetic and molecular basis of keratoglobus is warranted.