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Updated: Jun 23, 2025

Perspectives on Neuroscience
Published on: July 31, 2007
Editorial for the IJMS Special Issue on "Neurodevelopmental Disorders: From Epigenetic Basis to Therapeutic
Miriam Zappella1, Roberto Sacco2, Alessandra Micera3
1Department of Psychology, Salesian University of Rome, 00139 Rome, Italy.
Insights
This Special Issue explores the intricate mechanisms of neurodevelopmental disorders, which start in childhood and affect individuals throughout their lives. Understanding these complex neurological conditions is crucial for effective intervention.
Area of Science:
- Neuroscience
- Developmental Biology
- Psychiatry
Background:
- Focuses on neurodevelopmental disorders (NDDs) as defined by the DSM-5.
- Highlights the lifelong impact of NDDs, beginning in childhood.
- Addresses the complexity of underlying neurological mechanisms.
Discussion:
- Examines the multifaceted nature of NDDs.
- Considers the developmental trajectory from childhood to adulthood.
- Investigates the intricate biological pathways involved.
Key Insights:
- Complex mechanisms of NDDs are central to this issue.
- Early onset of NDDs has lasting consequences.
- DSM-5 classification provides a framework for understanding.
Outlook:
- Future research directions in NDDs.
- Potential for improved diagnostics and therapeutics.
- Longitudinal studies to track developmental impact.
Abstract:
In this Special Issue, we focus on the complex mechanisms underlying neurodevelopmental disorders (as delineated in the DSM-5), which are a group of neurological disorders that begin in childhood but significantly impact adult life [...].

