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Author Spotlight: Advancing Real-Time cAMP Detection in Cells Using cADDis Biosensor
Published on: March 22, 2024
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Cordycepin Triphosphate as a Potential Modulator of Cellular Plasticity in Cancer via cAMP-Dependent Pathways: An In
Jose Luis Gonzalez-Llerena1,2, Bryan Alejandro Espinosa-Rodriguez1, Daniela Treviño-Almaguer1
1Laboratory of Molecular Pharmacology and Biological Models, School of Chemistry, Autonomous University of Nuevo Leon, San Nicolas de los Garza 66451, Mexico.
International Journal of Molecular Sciences
|June 19, 2024
Summary
Cordycepin triphosphate may inhibit cancer cell signaling by blocking adenylate cyclase. This mechanism could enhance antitumor immunity by preventing immune cell changes driven by cyclic adenosine monophosphate (cAMP).
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Cordycepin (3'-deoxyadenosine) is an adenosine analog with diverse biological activities.
- Its unique structure, lacking a 3'-hydroxyl group, influences its biological interactions.
- Cordycepin is converted to cordycepin triphosphate in vivo.
Purpose of the Study:
- To analyze the structural features of cordycepin and its derivatives.
- To investigate the interaction of cordycepin triphosphate with adenylate cyclase.
- To explore cordycepin's potential anticancer mechanisms.
Main Methods:
- Chemoinformatics and bioinformatics analysis.
- Molecular dynamics simulations.
- Comparison with endogenous purine metabolites and adenosine triphosphate (ATP).
Main Results:
- Cordycepin triphosphate demonstrated comparable or superior binding scores to ATP at the adenylate cyclase active site.
- This interaction suggests cordycepin triphosphate acts as a pseudo-ATP, inhibiting cyclic adenosine monophosphate (cAMP) production.
- The 3'-hydroxyl group's absence prevents nucleotide cyclization.
Conclusions:
- Cordycepin may exert anticancer effects by modulating cAMP signaling pathways.
- This mechanism could potentially awaken antitumor immunity by stabilizing immune cell phenotypes.
- Provides a novel molecular insight into cordycepin's action within the tumor microenvironment.
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