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Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies

  • 0Department of Psychiatric Nursing, Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
International Journal of Molecular Sciences +

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June 19, 2024

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June 19, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Suicide neurobiology may involve glial cell changes. While total glial cells show no difference, specific types like astrocytes and oligodendrocytes decrease, and microglia activate in individuals with psychiatric disorders who died by suicide.

Area Of Science

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background

  • Suicide is a significant public health concern.
  • Its underlying molecular mechanisms are linked to glial cell abnormalities and gene expression changes.
  • Understanding the neurobiology of suicide is crucial for prevention.

Conclusions

  • Glial cell dysfunction, particularly changes in astrocytes, microglia, and oligodendrocytes, is implicated in the neurobiology of suicide.
  • While current data are complex, they suggest potential pathways for suicide risk and prevention strategies.
  • Further research is needed to fully understand the role of glial cells in suicidal behavior.

Keywords: