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Nrf2 Signaling Pathway as a Key to Treatment for Diabetic Dyslipidemia and Atherosclerosis

Michelle Yi1, Arvin John Toribio1, Yusuf Muhammad Salem1

  • 1Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.

International Journal of Molecular Sciences
|June 19, 2024
PubMed

Insights

Nuclear erythroid 2-related factor 2 (Nrf2) may combat diabetic dyslipidemia. This review explores Nrf2

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Diabetes mellitus (DM) affects millions, causing severe complications like atherosclerosis.
  • Diabetic dyslipidemia significantly increases the risk of stroke, coronary artery disease, and myocardial infarction.
  • Atherosclerosis in DM patients is a major cause of morbidity and mortality.

Purpose of the Study:

  • To explore the role of the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway in diabetic dyslipidemia.
  • To investigate cellular-level risk factors contributing to diabetic dyslipidemia.
  • To elucidate Nrf2 as a potential therapeutic target for DM-related atherosclerosis.

Main Methods:

  • Literature review focusing on Nrf2 pathway mechanisms.
  • Analysis of cellular risk factors in diabetic dyslipidemia.
  • Examination of therapeutic potential of Nrf2 in DM complications.

Main Results:

  • The Nrf2 pathway exhibits antioxidative properties relevant to DM.
  • Nrf2 activation may mitigate cellular damage associated with diabetic dyslipidemia.
  • Nrf2 presents a promising therapeutic avenue for DM-associated atherosclerosis.

Conclusions:

  • The Nrf2 pathway is a key player in managing diabetic dyslipidemia.
  • Targeting Nrf2 offers a novel strategy for treating DM complications.
  • Further research into Nrf2 modulation is warranted for cardiovascular health in DM patients.
Keywords:
Nrf2 pathwayantioxidantatherosclerosisdiabetes mellitusdyslipidemiaoxidative stress

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