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Updated: Jun 23, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
Published on: May 3, 2024
Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration
Burcak Yavuz1, Esra Cansever Mutlu2, Zubair Ahmed3
1Vocational School of Health Services, Altinbas University, 34147 Istanbul, Turkey.
Abstract:
Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.
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