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GDF15, an Emerging Player in Renal Physiology and Pathophysiology
Samia Lasaad1, Gilles Crambert2,3
1Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
International Journal of Molecular Sciences
|June 19, 2024
Summary
Growth Differentiation Factor 15 (GDF15) is a stress-related hormone impacting kidney function and homeostasis. This review explores GDF15's crucial roles in both healthy and diseased kidneys.
Area of Science:
- Nephrology
- Endocrinology
- Molecular Biology
Background:
- Growth Differentiation Factor 15 (GDF15) is recognized as a key mediator in diverse biological processes.
- It functions as a stress-related hormone, elevated during various pathological conditions.
- GDF15 has been implicated in numerous kidney diseases, including chronic kidney disease, diabetic nephropathy, and renal cancer.
Purpose of the Study:
- To review the multifaceted roles of GDF15 in renal physiology.
- To elucidate the involvement of GDF15 in the pathogenesis of kidney diseases.
- To highlight GDF15's function in maintaining renal homeostasis, including plasma pH and potassium levels.
Main Methods:
- Literature review of recent studies on GDF15 and kidney function.
- Analysis of GDF15's involvement in established renal pathologies.
- Examination of GDF15's role in physiological mechanisms of renal homeostasis.
Main Results:
- GDF15 is a significant factor in multiple kidney pathologies.
- Emerging evidence points to GDF15's role in regulating critical homeostatic parameters in the kidney.
- GDF15 acts as a protective or detrimental factor depending on the specific renal context.
Conclusions:
- GDF15 plays a critical role in kidney health and disease.
- Understanding GDF15's renal effects is vital for developing new therapeutic strategies.
- Further research into GDF15's homeostatic functions could reveal novel insights into kidney regulation.
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