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Updated: Jun 23, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Generalized Pustular Psoriasis and Systemic Organ Dysfunctions.

Romane Teshima¹, Natsuko Saito-Sasaki¹, Yu Sawada¹

¹Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

International Journal of Molecular Sciences

|June 19, 2024

Summary

This summary is machine-generated.

Generalized pustular psoriasis (GPP) significantly impacts systemic health, increasing risks for cardiovascular, liver, kidney, and lung diseases. Effective GPP management requires addressing its widespread effects beyond the skin.

Keywords:

IL-36 generalized pustular psoriasis systemic organ dysfunctions

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Published on: October 12, 2012

Area of Science:

Dermatology
Immunology
Systemic Pathology

Background:

Generalized pustular psoriasis (GPP) is a severe inflammatory skin condition.
GPP is linked to systemic comorbidities affecting multiple organ systems.

Purpose of the Study:

To review the systemic diseases associated with GPP.
To elucidate the role of cytokines in GPP and its systemic manifestations.

Main Methods:

Literature review of studies on GPP and systemic diseases.
Analysis of cytokine involvement (IL-17, IL-36) in GPP pathophysiology.

Main Results:

GPP patients exhibit higher cardiovascular event rates, particularly myocardial infarction.
Associated conditions include liver disturbances, renal dysfunction, lung disease, osteoporosis, anemia, and mental health issues.
Cytokines IL-17 and IL-36 are implicated in GPP pathogenesis and systemic complications.

Conclusions:

GPP necessitates a holistic management approach addressing both skin and systemic aspects.
Further research is needed to understand GPP's systemic mechanisms for improved therapies.