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Role of Complement Components in Asthma: A Systematic Review.
Ilona Tornyi1, Ildikó Horváth1,2
1Department of Pulmonology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Journal of Clinical Medicine
|June 19, 2024
Summary
This study found elevated complement regulatory proteins, like Factor H, in asthma patients, suggesting a role in disease pathophysiology. Further research is needed to explore their potential as asthma biomarkers.
Area of Science:
- Immunology
- Respiratory Medicine
- Complement System Biology
Background:
- Asthma is a chronic airway inflammatory disease involving both innate and adaptive immunity.
- The complement system, crucial for immune defense, bridges innate and adaptive responses.
- While animal models show complement activation in asthma, human data is limited.
Purpose of the Study:
- To systematically review the role of the complement system in human asthma patients.
- To identify complement factors associated with asthma pathogenesis and severity.
Main Methods:
- Systematic literature review of studies on the complement system in asthma.
- Searched PubMed, Web of Science, Scopus, and Google Scholar databases.
- Included studies meeting specific eligibility criteria, with protocol registered on OSF.
Main Results:
- 24 articles met eligibility criteria from 482 initially identified.
- Heterogeneity observed in study samples, methods, and populations.
- Consistently elevated levels of complement regulatory proteins, including Factor H, in asthma patients compared to healthy controls.
Conclusions:
- Increased levels of regulatory proteins like Factor H and I may influence asthma pathophysiology.
- Complement factors warrant further investigation as potential biomarkers for asthma activity and severity.
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