SCORE2 Screening Tool for Cardiovascular Risk Assessment in Psoriasis-A Case-Control Study

Area of Science:

• Cardiology
• Dermatology
• Public Health

Background:

• Psoriasis is a T-cell-mediated inflammatory skin disease linked to increased cardiovascular disease (CVD) risk factors and events.
• Cardiovascular risk stratification is essential for managing psoriasis patients due to their elevated CVD risk.
• SCORE2 and SCORE2-OP algorithms predict 10-year CVD risk in European populations.

Purpose of the Study:

• To evaluate cardiovascular risk in Slovak psoriasis patients using SCORE2 and SCORE2-OP scoring systems.
• To investigate the relationship between cardiovascular risk and psoriasis features in a real-world setting.

Main Methods:

• A case-control study involving 115 outpatients with plaque psoriasis and 66 matched controls.
• Utilized SCORE2 and SCORE2-OP algorithms for cardiovascular risk assessment.
• Linear regression analysis to determine relationships between cardiovascular risk and patient/psoriasis variables.

Main Results:

• Psoriasis patients demonstrated significantly higher mean SCORE2 cardiovascular risk scores compared to controls.
• A higher proportion of psoriasis patients, particularly those under 50, were classified as moderate or high risk.
• Psoriasis patients exhibited higher BMI, waist circumference, total cholesterol, LDL, and systolic blood pressure; they were also more likely to be smokers.

Conclusions:

• Strong association exists between cardiovascular risk factors and psoriasis.
• Cardiovascular risk stratification is increasingly important for psoriasis patients.
• Preventive lifestyle changes and therapeutic interventions are warranted for psoriasis patients to mitigate cardiovascular risk.