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Updated: Jun 23, 2025

Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
Drug-Modified Contact Lenses-Properties, Release Kinetics, and Stability of Active Substances with Particular
Iwona Rykowska1, Ola Michałkiewicz1, Iwona Nowak1
1Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland.
Abstract:
The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.
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