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Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their

Maren Lerfald1,2, Heather Allore3,4, Tom I L Nilsen1,5

  • 1Faculty of Medicine and Health Science, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|June 19, 2024
PubMed

Insights

Maintaining healthy blood pressure and good cardiorespiratory fitness throughout adulthood is linked to a lower risk of dementia. These combined lifestyle factors may significantly reduce dementia incidence.

Area of Science:

  • Neuroscience
  • Cardiology
  • Public Health

Background:

  • High blood pressure and low cardiorespiratory fitness are known dementia risk factors.
  • Few studies have investigated combined longitudinal patterns of these modifiable risk factors.

Purpose of the Study:

  • To identify combined trajectories of blood pressure and cardiorespiratory fitness.
  • To examine the association between these trajectories and dementia risk.

Main Methods:

  • Prospective cohort study using Trøndelag Health (HUNT) Study data.
  • Group-based multidimensional trajectory modeling to identify SBP, DBP, and fitness patterns.
  • Logistic regression to analyze dementia risk (ORs, RDs).

Main Results:

  • Two trajectories identified: 'poorer' (high BP, low fitness) and 'better' (low BP, high fitness).
  • The 'better' trajectory group showed consistently lower dementia risk across age groups.
  • Lowest odds ratio (OR) of 0.63 in the middle-aged group for the 'better' trajectory.

Conclusions:

  • Beneficial combined trajectories of blood pressure and cardiorespiratory fitness reduce dementia risk.
  • Optimizing SBP, DBP, and fitness throughout adulthood may be a key strategy for dementia prevention.
Abstract

Keywords:
CardiovascularCognitionPrevention

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