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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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Other Pulmonary Disorders01:17

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Correlations02:20

Correlations

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Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
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NREM Sleep
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Cause and Effect01:53

Cause and Effect

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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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Related Experiment Video

Updated: Jun 23, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Causal Relationships Between Circulating Inflammatory Proteins and Obstructive Sleep Apnea: A Bidirectional Mendelian

Zhengjie Chen1,2, Jinjie Zeng3, Xiang Pei1,2

  • 1Clinical School of Thoracic, Tianjin Medical University, Tianjin, People's Republic of China.

Nature and Science of Sleep
|June 19, 2024
PubMed
Summary

This study used Mendelian randomization to explore links between circulating inflammatory proteins and obstructive sleep apnea (OSA). Several proteins were found to influence OSA risk or be affected by OSA, suggesting potential therapeutic targets.

Keywords:
Mendelian randomizationbidirectionalcirculating inflammatory proteinsobstructive sleep apnea

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Area of Science:

  • Genetics
  • Immunology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is linked to inflammation.
  • Understanding the causal relationship between inflammatory proteins and OSA is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the causal links between 91 circulating inflammatory proteins (CIPs) and obstructive sleep apnea (OSA).
  • To identify potential upstream and downstream regulatory proteins associated with OSA through Mendelian randomization (MR).

Main Methods:

  • A bidirectional Mendelian randomization (MR) study was conducted.
  • Genetic data for OSA was sourced from the FinnGen Genome-wide Association Studies (GWAS) of European individuals.
  • Summary-level GWAS data for 91 CIPs from 14,824 European participants was utilized.

Main Results:

  • Several CIPs were associated with OSA risk: IL-17C, CCL25, FGF-5, CD5, and TNFSF14 showed positive correlation, while IL-20RA, CCL19, MIP-1 alpha, Flt3L, CST5, OPG, and TRAIL showed negative correlation.
  • OSA was associated with elevated IL-10RA levels and decreased levels of CCL28, DNER, FGF-21, and CSF-1.
  • The study identified 12 upstream regulatory proteins and 5 downstream effect proteins linked to OSA.

Conclusions:

  • This MR study identified specific circulating inflammatory proteins causally linked to OSA.
  • The findings highlight potential therapeutic targets for addressing the inflammatory mechanisms involved in OSA.