Significance of Nutritional-Inflammatory Index as Predictors for Total Neoadjuvant Therapy-Induced Tumor Regression in Locally Advanced Rectal Cancer Patients
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View abstract on PubMed
Summary
This summary is machine-generated.Large tumor diameter and low HALP predict poor tumor regression in locally advanced rectal cancer patients receiving total neoadjuvant therapy (TNT). These factors are crucial for predicting treatment response.
Area Of Science
- Oncology
- Clinical Research
- Cancer Therapeutics
Background
- Locally advanced rectal cancer (LARC) requires effective treatment strategies.
- Total neoadjuvant therapy (TNT) is increasingly used for LARC.
- Predicting treatment response in LARC undergoing TNT is essential for personalized care.
Purpose Of The Study
- To evaluate the predictive capacity of clinicopathological characteristics and the nutritional-inflammatory index for treatment response in LARC patients receiving TNT.
- To identify factors associated with favorable or poor responses to TNT.
Main Methods
- Retrospective analysis of 127 LARC patients treated with TNT.
- Comparison of clinicopathological characteristics based on TNT response.
- Logistic regression analysis to identify predictors of TNT-induced tumor regression.
Main Results
- Seventy patients (55.1%) had a favorable response, while 57 (44.9%) had a poor response to TNT.
- Large tumor diameter (> 5.0 cm) and low HALP (≤ 40) were significant predictors of poor TNT response.
- Low HALP showed a trend towards increased recurrence risk, though not statistically significant.
Conclusions
- Large tumor diameter and low HALP predict poor tumor regression in LARC patients treated with CAPOX-based TNT.
- These findings can aid in stratifying patients and optimizing treatment strategies for LARC.
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