Intestinal Targeted Nanogel with Broad-Spectrum Autonomous ROS Scavenging Performance for Enhancing the Bioactivity...

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Oxidative Stress Research

Background:

• Improving the bioavailability of trans-resveratrol (trans-Res) is crucial for its therapeutic applications.
• Complex synthetic carriers for trans-Res often present practical challenges in application.

Purpose of the Study:

• To develop a novel, intestinal-targeted nanogel (Ngel) for enhanced delivery and bioavailability of trans-Res.
• To evaluate the stability, ROS scavenging activity, and in vivo efficacy of trans-Res loaded within the Ngel system.

Main Methods:

• A nanogel (Ngel) was synthesized using selenized thiolated sodium alginate (TSA-Se) and crosslinked with calcium lactate (CL).
• The Ngel was loaded with trans-resveratrol (trans-Res) to form Ngel@Res, designed for intestinal release.
• The efficacy of Ngel@Res was assessed in Caenorhabditis elegans, measuring lifespan and key gene/enzyme expressions.

Main Results:

• The Ngel system maintained spherical morphology in the upper digestive tract and released trans-Res in the lower digestive tract.
• Ngel protected trans-Res, enhancing its stability and broad-spectrum ROS scavenging activity.
• Ngel@Res significantly increased the lifespan of C. elegans by modulating antioxidant defense pathways.

Conclusions:

• The developed selenized alginate-based nanogel is an effective intestinal-targeted delivery system for trans-Res.
• This approach readily improves the bioactivity and bioavailability of trans-Res.
• The Ngel system offers a promising strategy for enhancing the therapeutic potential of antioxidants.