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Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Related Experiment Video

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Epigenetic modifications in abdominal aortic aneurysms: from basic to clinical.

YuChen Liu1, XiaoYun Sun1, Zhen Gou1

  • 1Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning, China.

Frontiers in Cardiovascular Medicine
|June 19, 2024
PubMed
Summary

Epigenetic mechanisms like DNA methylation and non-coding RNAs are crucial in abdominal aortic aneurysm (AAA) development. Targeting these epigenetic factors offers new therapeutic strategies for AAA beyond surgery.

Keywords:
DNA methylationabdominal aortic aneurysmepigeneticshistone modificationnon-coding RNA

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Epigenetics

Background:

  • Abdominal aortic aneurysm (AAA) is a life-threatening condition with high mortality and limited targeted therapies.
  • AAA involves complex multifactorial processes leading to aortic dilation and rupture.
  • Current treatments for AAA primarily rely on surgical interventions.

Purpose of the Study:

  • To systematically review the role of epigenetic regulation in the development of AAA.
  • To identify key genes, pathways, and epigenetic mechanisms implicated in AAA pathogenesis.
  • To explore the potential of epigenetics-based therapies for AAA treatment.

Main Methods:

  • Comprehensive literature review of studies on epigenetic regulation in AAA.
  • Analysis of DNA methylation, histone modification, non-coding RNA, and RNA modification in AAA.
  • Identification of relevant genes and signaling pathways involved in AAA.

Main Results:

  • Epigenetic alterations, including DNA methylation, histone modifications, and non-coding RNAs, significantly contribute to AAA.
  • Specific genes and pathways regulated by epigenetic mechanisms are identified as potential therapeutic targets.
  • Abnormal gene expression due to epigenetic dysregulation is a key factor in AAA occurrence.

Conclusions:

  • Epigenetic regulation is a critical determinant in AAA pathogenesis.
  • Targeting epigenetic mechanisms presents a promising avenue for novel AAA therapeutic strategies.
  • Understanding AAA epigenetics can lead to improved clinical treatments and patient outcomes.