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Updated: Jun 23, 2025
A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
Published on: September 16, 2022
Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine
Xingli Dong1, Yusheng Lin2,3,4,5, Kai Li4,5
1558113 Central Laboratory, Department of Hematology and Oncology, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen Clinical Research Center for hematologic disease, Shenzhen University General Hospital , Shenzhen, Guangdong, China.
Extracellular vesicles (EVs), including exosomes and microvesicles, are key biomarkers found in body fluids. This consensus statement highlights their potential in liquid biopsy and clinical applications for diseases like cancer.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Background:
- Extracellular vesicles (EVs) are nanoscale membrane vesicles released by cells.
- EVs encompass exosomes and microvesicles, differing in origin and size.
- Disease-derived EVs in body fluids offer molecular insights into cellular origins.
Purpose of the Study:
- To present expert perspectives on extracellular vesicle (EV) research and product development.
- To emphasize the translation of EV knowledge into clinical applications, especially as disease biomarkers.
- To address the merits, challenges, and future directions in EV-based diagnostics and therapeutics.
Main Methods:
- Consensus-based collective statement from leading researchers.
- Review of current understanding and challenges in EV research.
- Discussion of clinical translation strategies for EV applications.
Main Results:
- EVs are recognized as valuable tools for liquid biopsy.
- Significant potential exists for EVs as biomarkers in cancer and other diseases.
- Ongoing research and development are crucial for clinical translation.
Conclusions:
- Extracellular vesicles hold immense promise for advancing liquid biopsy and disease diagnostics.
- Addressing current challenges is essential for realizing the full clinical potential of EVs.
- Collaborative efforts are vital to accelerate breakthroughs in EV research and application.
