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Published on: December 6, 2021
Cobalt ferrite nanoparticles for annulation of C3-substituted nitroarenes and aryl isothiocyanates
Phong D Nguyen1,2, Truong K Chau1,2, Mai Q Le2,3
1VNU-HCM Key Laboratory of Functional Organic Materials, 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam. tungtn@hcmut.edu.vn.
Abstract:
The synthesis of medicinally relevant N-aryl-substituted 2-aminobenzothiazoles often uses 2-aminothiophenol derivatives, which are not commercially abundant, as starting materials. Herein, we report a method for the annulation of C3-substituted nitroarenes and aryl isothiocyanates towards the synthesis of 2-aminobenzothiazoles. Reactions proceeded in the presence of cobalt ferrite nanoparticles as a catalyst, DABCO as a base, and DMF as a promoter. The cobalt ferrite nanoparticles could be recovered after each run and reused up to 3 times while the product yield was not diminished. Our method appears to be the first example of the direct use of substituted nitroarenes for yielding 2-aminobenzothiazoles.
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