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Published on: September 26, 2018
Association Between Cardiovascular Health and Cirrhosis and Mortality: Insights From a Comprehensive Cross-sectional
Ziqing Yu1, Xuemin Yan1, Xiaoyin Bai1
1Departments of Gastroenterology.
Insights
Life's Essential 8 (LE8) cardiovascular health indicator is not directly linked to cirrhosis. However, improved health behaviors show a connection to lower cirrhosis risk and reduced mortality in patients with the condition.
Area of Science:
- Cardiovascular Health
- Liver Disease Research
- Public Health
Background:
- Cirrhosis presents a growing global health challenge with increasing mortality rates.
- Cardiovascular health (CVH) is increasingly recognized for its potential impact on liver disease progression.
- The study investigates the novel Life's Essential 8 (LE8) metric in relation to cirrhosis.
Purpose of the Study:
- To examine the association between the Life's Essential 8 (LE8) score and the prevalence of cirrhosis.
- To explore the relationship between LE8 components and cirrhosis risk.
- To assess the impact of LE8 on all-cause mortality in individuals with cirrhosis.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (2005-2018) for participants aged 20 and above.
- Assessed cardiovascular health using the Life's Essential 8 (LE8) score, encompassing 4 health behaviors and 4 health factors.
- Defined cirrhosis based on liver function tests (AST/Platelet Ratio Index >2) and tracked all-cause mortality via the National Death Index.
Main Results:
- No direct association was found between the Life's Essential 8 (LE8) score and cirrhosis.
- A higher score in the health behaviors component of LE8 was associated with a lower prevalence of cirrhosis.
- An inverse U-shaped relationship was observed between the LE8 score and all-cause mortality in cirrhosis patients, with benefits seen above a score of 60.
- Enhanced health behaviors significantly reduced all-cause mortality proportion among cirrhosis patients.
Conclusions:
- While LE8 itself isn't directly linked to cirrhosis, its health behaviors component is associated with lower cirrhosis prevalence.
- Prioritizing healthy lifestyle choices, including diet, exercise, and smoking cessation, may offer significant benefits for individuals with cirrhosis.
- Improving cardiovascular health through established behaviors could be a key strategy in managing cirrhosis and its complications.
Goal:
We aim to explore the relationship between the newly introduced CVH indicator "Life's Essential 8 (LE8)" and cirrhosis.
Background:
The global burden of cirrhosis is increasing, with a rising number of deaths, leading to significant societal and economic challenges. Cardiovascular health (CVH) has been found to have potential associations with liver diseases.
Materials And Methods:
All participants aged 20 and older from National Health and Nutrition Examination Survey 2005 to 2018 were included. CVH was accessed by LE8, consisting of 4 health behaviors (diet, physical activity, nicotine exposure, and sleep health) and 4 health factors (body mass index, lipid levels, blood sugar, and blood pressure). Cirrhosis was determined based on abnormal liver function test results, with an aspartate aminotransferase to platelet ratio index >2. Participants' mortality status was obtained by matching with the National Death Index and all-cause mortality served as the follow-up endpoint.
Results:
This extensive cross-sectional study reveals that LE8 was not associated with cirrhosis. A higher health behaviors score was associated with lower cirrhosis. Moreover, there is an inverse U-shaped relationship between the LE8 score and all-cause mortality in participants with cirrhosis, signifying a decrease in all-cause mortality when LE8 surpasses 60. A greater health behaviors score is linked to a decreased proportion of all-cause mortality in cirrhosis patients.
Conclusion:
Maintaining better health behaviors may be beneficial for cirrhosis, especially through a balanced diet, regular exercise, smoking cessation, and quality sleep.
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