Related Experiment Video
Updated: Aug 12, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Darkness, ethanol and cerebral activity
Abstract:
The effect of phase-shift in photoperiod on the mouse's locomotor activity, water and food consumption was studied. The mouse sensitivity to the toxicity of ethanol, as measured by duration of narcosis time, was assessed. Determination of cerebral activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) was made in specific mouse and rat brain regions. Animals were exposed for short-term of a 12 hr light and 12 hr darkness schedule or to continuous darkness. Motility counts showed inconsistent profile followed by a reduced frequency of occurrences in mice housed in complete darkness compared to controls. Mice slept longer from controls under ethanol narcosis when housed for 42 days in darkness. These mice showed a reduction of cortex ADH and ALDH occurring 24 hr post narcosis. Rats housed under continuous darkness showed a transient induction of ADH in some of the brain regions studied from 27 to 84 day period compared to inhibition of ALDH and ADH in certain mouse brain regions after 37 days of similar environmental condition. The results indicate species-dependent darkness induced alteration of cerebral activities of ADH and ALDH. The increased sensitivity towards the toxicity of ET by housing under continuous darkness is suggested, and the implication of such rhythm changes is discussed.
Related Concept Videos
Physical Properties of Ethers
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
Autoxidation of Ethers to Peroxides and Hydroperoxides
CNS Depressants: Alcohol and Nicotine
Production of Alcohol

