Related Experiment Video

Updated: Jun 23, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.7K

Association between exposure to organophosphorus pesticide and suicidal ideation among U.S. adults: A

Mo-Yao Tan1, Shan Wu2, Si-Xuan Zhu2

  • 1Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, China.

Ecotoxicology and Environmental Safety
|June 19, 2024
PubMed
Abstract

Insights

Exposure to organophosphorus pesticides (OPPs), particularly dimethylthiophosphate (DMTP), is linked to increased suicidal ideation (SI) in adults. Young and older men show heightened susceptibility to these pesticide effects.

Area of Science:

  • Environmental Health
  • Neuroscience
  • Public Health

Background:

  • Organophosphorus pesticides (OPPs) are widely used, raising concerns about potential neurotoxic effects.
  • Suicidal ideation (SI) is a significant public health issue with multifactorial causes.
  • Understanding environmental risk factors for SI is crucial for prevention strategies.

Purpose of the Study:

  • To investigate the association between exposure to organophosphorus pesticides (OPPs) and suicidal ideation (SI) in adults.
  • To identify specific OPP metabolites and population subgroups most vulnerable to these effects.
  • To assess the cumulative impact and interactions of multiple OPP exposures on SI.

Main Methods:

  • Utilized data from four cycles of the National Health and Nutrition Examination Survey (NHANES) with 5244 adult participants.
  • Assessed SI using the Patient Health Questionnaire-9 and measured OPP metabolite levels in urine samples.
  • Employed multivariate logistic regression, WQS regression, and BKMR models for association and cumulative impact analyses, including stratified analyses by demographics and health status.

Main Results:

  • Dimethylthiophosphate (DMTP) showed a statistically significant positive association with SI (OR: 1.18).
  • WQS and BKMR models confirmed a significant association between mixed OPP metabolites and SI, with DMTP being a major contributor.
  • Stratified analyses revealed a pronounced effect of OPPs on SI in young and older men.

Conclusions:

  • Exposure to DMTP is associated with an increased risk of suicidal ideation (SI).
  • Young adult males and older males are particularly susceptible to the adverse mental health effects of OPP exposure.
  • These findings highlight the need for further research into environmental toxins as potential contributors to suicidal ideation.
Keywords:
Cross-sectional studyMixed exposureNHANESOrganophosphorus insecticidesSuicidal ideation

More Related Videos

Bioassays for Monitoring Insecticide Resistance06:30

Bioassays for Monitoring Insecticide Resistance

Published on: December 30, 2010

33.3K
Determination of the Absorption, Translocation, and Distribution of Imidacloprid in Wheat06:11

Determination of the Absorption, Translocation, and Distribution of Imidacloprid in Wheat

Published on: April 28, 2023

1.8K

Related Concept Videos

Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
845
Preparedness and Phobias01:09

Preparedness and Phobias

Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
99
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
75
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
97
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
30