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The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency
Oliver T Burton1, Orian Bricard2, Samar Tareen2
1Department of Pathology, University of Cambridge, Cambridge, UK; VIB Center for Brain and Disease Research, Leuven, Belgium; KU Leuven, University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium; Babraham Institute, Babraham Research Campus, Cambridge, UK.
Immunity
|June 19, 2024
Summary
Regulatory T (Treg) cells in tissues exhibit unique, shared traits across the body. These broadly self-reactive Treg cells migrate transiently, suggesting common mechanisms safeguard bodily homeostasis.
Area of Science:
- Immunology
- Cell Biology
- Tissue Homeostasis
Background:
- Tissues are crucial sites for immunological reactions, but immune system control within them is poorly understood.
- Foxp3-positive regulatory T (Treg) cells in non-lymphoid tissues show distinct characteristics compared to lymphoid Treg cells.
- A comprehensive understanding of tissue Treg cells across diverse non-lymphoid organs is lacking.
Purpose of the Study:
- To systematically analyze the Treg cell population across various non-lymphoid organs.
- To identify shared phenotypes, residency patterns, and molecular dependencies of tissue-resident Treg cells.
- To elucidate the migratory and functional properties of Treg cells in maintaining tissue homeostasis.
Main Methods:
- Systematic analysis of Treg cell populations in non-lymphoid organs.
- T-cell receptor (TCR) sequencing to assess Treg cell clonality and shared sequences.
- Assessment of Treg cell homing properties and migratory behavior across tissues.
Main Results:
- Tissue Treg cells from different non-lymphoid organs share common T-cell receptor (TCR) sequences.
- These Treg cells demonstrate functional capacity for multi-tissue entry and exhibit tissue-agnostic homing.
- The Treg cell pool in most non-lymphoid organs (excluding the gut) comprises broadly self-reactive cells with transient multi-tissue migration.
Conclusions:
- Tissue-resident Treg cells display shared phenotypes, transient residency, and common molecular dependencies across non-lymphoid organs.
- Broadly self-reactive Treg cells with transient migratory capacity constitute the Treg pool in many non-lymphoid tissues.
- Common regulatory mechanisms likely enable pan-tissue Treg cells to maintain bodily homeostasis.
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