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Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Updated: Jun 23, 2025

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

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Published on: August 6, 2014

Capturing embryonic hematopoiesis in temporal and spatial dimensions.

Bart Weijts¹, Catherine Robin²

¹Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.

Experimental Hematology

|June 19, 2024

Summary

This summary is machine-generated.

Hematopoietic stem cells (HSCs) originate during embryonic development. Live imaging reveals their birth, development, and niche interactions, advancing our understanding of blood cell production.

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Last Updated: Jun 23, 2025

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

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Isolation of Murine Embryonic Hemogenic Endothelial Cells

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

Area of Science:

Developmental biology
Hematopoiesis
Stem cell biology

Background:

Hematopoietic stem cells (HSCs) are crucial for lifelong blood cell production.
HSCs originate during embryonic development, not solely in adult bone marrow.
Understanding HSC origins and interactions is key to hematopoiesis research.

Purpose of the Study:

To review advancements in understanding HSC origin and production during embryonic development.
To highlight the role of live imaging in studying HSC development and niche interactions.
To explore cellular interactions within the HSC microenvironment.

Main Methods:

Utilizing intravital imaging techniques on live embryos (mice and zebrafish).
Analyzing non-fixed samples to observe dynamic cellular processes.
Focusing on imaging studies that track HSCs and their surrounding niche.

Main Results:

Live imaging provides critical insights into the anatomical and cellular origins of HSCs.
Dynamic interactions between HSCs and niche cells (e.g., endothelial cells, macrophages) are visualized.
Developmental trajectories and niche-specific interactions are elucidated.

Conclusions:

Intravital imaging has revolutionized the study of embryonic HSC development.
Understanding HSC origins and niche interactions is vital for hematopoiesis.
Future research can build upon imaging insights to explore HSC regulation.