Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential release of bioactive factors from functionalized metal-organic framework hydrogel enhances interfacial osseointegration of 3D-printed titanium alloy porous scaffolds.

Theranostics·2025
Same author

Genetic Engineered Ultrasound-Triggered Injectable Hydrogels for Promoting Bone Reconstruction.

Research (Washington, D.C.)·2025
Same author

Deferoxamine functionalized alginate-based collagen composite material enhances the integration of metal implant and bone interface.

Carbohydrate polymers·2024
Same author

PLGA-based electrospun nanofibers loaded with dual bioactive agent loaded scaffold as a potential wound dressing material.

Colloids and surfaces. B, Biointerfaces·2023
Same author

Application of metabolomics in osteoporosis research.

Frontiers in endocrinology·2022
Same author

Total synthesis of phorboxazole A via de novo oxazole formation: convergent total synthesis.

Journal of the American Chemical Society·2010

Related Experiment Video

Updated: May 11, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

10.7K

Growth factor-functionalized titanium implants for enhanced bone regeneration: A review.

Zhenjia Che1, Qi Sun1, Zhenyu Zhao1

  • 1Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China.

International Journal of Biological Macromolecules
|June 19, 2024
PubMed
Summary

Titanium implants release growth factors to enhance bone regeneration and implant integration. This approach improves osseointegration and reduces complications in orthopedic applications.

Keywords:
BiomaterialsGrowth factorTitanium implant

More Related Videos

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.3K
Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

2.3K

Related Experiment Videos

Last Updated: May 11, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

10.7K
Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.3K
Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

2.3K

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Regenerative Medicine

Background:

  • Titanium and its alloys are preferred for orthopedic implants due to excellent mechanical strength and biocompatibility.
  • Local delivery of bioactive substances, particularly growth factors, enhances bone tissue formation and osseointegration.
  • Growth factors exhibit potent osteogenic and angiogenic properties crucial for bone regeneration.

Purpose of the Study:

  • To review the types, mechanisms, and loading techniques of growth factors for titanium implants.
  • To explore recent advancements in surface functionalization of titanium implants with growth factors.
  • To discuss limitations and future directions for growth factor-functionalized titanium implants in bone tissue engineering.

Main Methods:

  • Comprehensive literature review on growth factor applications in orthopedic implants.
  • Analysis of various physical, chemical, and biological methods for growth factor loading onto titanium surfaces.
  • Examination of controlled release kinetics and their impact on biological outcomes.

Main Results:

  • Growth factor-loaded titanium implants demonstrate enhanced osseointegration compared to conventional implants.
  • Localized delivery minimizes systemic side effects and improves treatment efficacy.
  • Diverse loading strategies enable tailored release profiles for optimal bone regeneration.

Conclusions:

  • Growth factor functionalization represents a significant advancement in enhancing the bone regenerative capacity of titanium implants.
  • This strategy holds great promise for improving outcomes in orthopedic surgery and bone tissue engineering.
  • Further research into optimized delivery systems and factor combinations is warranted.