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Design, optimization and characterization of atorvastatin loaded chitosan-based polyelectrolyte complex nanoparticles
Pravin Patil1, Ankit Vankani1, Krutika Sawant1
1Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara 390001, Gujarat, India.
International Journal of Biological Macromolecules
|June 19, 2024
Summary
This study developed atorvastatin (ATO) loaded chitosan-based polyelectrolyte complex nanoparticles (PECN) transdermal patches. The novel patch significantly enhanced ATO skin permeability and bioavailability compared to oral tablets.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Drug Delivery Systems
Background:
- Atorvastatin (ATO) exhibits poor bioavailability, necessitating advanced delivery systems.
- Chitosan-based polyelectrolyte complex nanoparticles (PECN) offer potential for improved drug delivery.
- Transdermal patches provide a non-invasive route for drug administration.
Purpose of the Study:
- To develop and evaluate atorvastatin (ATO) loaded chitosan-based polyelectrolyte complex nanoparticles (PECN) incorporated into a transdermal patch.
- To enhance the skin permeability and bioavailability of ATO through a novel transdermal delivery system.
Main Methods:
- ATO-loaded PECN were prepared using the ionic gelation method and optimized with Box-Behnken design.
- Physicochemical characteristics, in vitro, ex vivo, cell line, and stability studies were conducted.
- Optimized ATO-PECN were incorporated into transdermal patches, followed by comprehensive evaluation.
Main Results:
- Optimized ATO-PECN exhibited a particle size of 219.2 ± 5.98 nm, 82.68 ± 2.63% entrapment, and +25.41 ± 3.29 mV zeta potential.
- ATO-PECN demonstrated sustained drug release, enhanced skin permeation, and increased cell permeability compared to ATO suspension.
- The transdermal patch showed superior ex vivo skin permeation and significantly improved in vivo pharmacokinetic parameters, confirming enhanced bioavailability.
Conclusions:
- The developed atorvastatin-loaded PECN transdermal patch is a promising drug delivery system.
- This novel system effectively enhances the bioavailability of poorly bioavailable drugs like atorvastatin.
- The study highlights the potential of chitosan-based PECN for advanced transdermal drug delivery applications.
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