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Ubiquitination in viral entry and replication: Mechanisms and implications
Maria Velez-Brochero1, Padmanava Behera1, Kazi Sabrina Afreen1
1Center for Virus-Host-Innate Immunity and Department of Medicine, Rutgers Biomedical and Health Sciences, Institute for Infectious and Inflammatory Diseases, Rutgers University, Newark, NJ, United States.
Advances in Virus Research
|June 19, 2024
Summary
Viruses exploit the ubiquitination process for entry and replication. Understanding this interaction is key to developing new antiviral therapies targeting the ubiquitin system.
Area of Science:
- Biochemistry
- Virology
- Cell Biology
Background:
- Ubiquitination is a vital posttranslational modification regulating cellular processes like immunity and protein degradation.
- Viruses leverage the host ubiquitination system for replication, immune evasion, and enhanced pathogenesis.
- Enveloped viruses may utilize free or protein-bound ubiquitin to facilitate host cell entry.
Purpose of the Study:
- To review the intricate interplay between viral hijacking of the ubiquitination process and host-virus battles.
- To emphasize the role of ubiquitination in viral entry and replication cycle progression.
- To explore therapeutic strategies targeting the ubiquitin system for novel antiviral drug discovery.
Main Methods:
- Literature review focusing on ubiquitination in viral infections.
- Analysis of viral strategies to manipulate host ubiquitination machinery.
- Discussion of ubiquitination's impact on viral tropism and pathogenesis.
Main Results:
- Viruses actively exploit ubiquitination for various stages of their life cycle, including entry.
- Ubiquitination of viral proteins can influence viral tropism and infection efficiency.
- The ubiquitin system represents a promising target for antiviral interventions.
Conclusions:
- The ubiquitination system is a critical battleground between viruses and host immunity.
- Targeting viral manipulation of ubiquitination offers a viable strategy for antiviral drug development.
- Further research into ubiquitination's role in viral pathogenesis can unlock new therapeutic avenues.
Keywords:
DeubiquitinasesInnate immunityTropismUbiquitinUbiquitin ligasesUnanchored ubiquitinViral antagonismViral pathogenesisVirus entryVirus uncoatingMore Related Videos
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