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Related Concept Videos

Bioremediation00:46

Bioremediation

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Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
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Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

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Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
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Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
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Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems01:19

Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems

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Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
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  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Agricultural Biotechnology
  9. Agricultural Biotechnology Diagnostics (incl. Biosensors)
  11. Detoxification Of Aflatoxin B1 By Phytochemicals In Agriculture And Food Science.
  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Agricultural Biotechnology
  9. Agricultural Biotechnology Diagnostics (incl. Biosensors)
  11. Detoxification Of Aflatoxin B1 By Phytochemicals In Agriculture And Food Science.

Related Experiment Video

RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
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RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem

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Detoxification of Aflatoxin B1 by Phytochemicals in Agriculture and Food Science.

Dian Yang1, Sihua Zhang1, Hongda Cao1

  • 1Key Laboratory of Saline-Alkali Vegetation Ecology Restoration (Northeast Forestry University), Ministry of Education, Heilongjiang Key Laboratory of Plant Bioactive Substance Biosynthesis and Utilization, College of Life Science, Northeast Forestry University, Harbin 150040, China.

Journal of Agricultural and Food Chemistry
|June 19, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Natural plant products show promise in combating Aflatoxin B1 (AFB1) contamination in food and feed. These phytochemicals offer low toxicity and utilize antioxidative, anti-inflammatory, and antiapoptotic pathways to mitigate AFB1

Keywords:
aflatoxin B1agriculturedetoxificationfood safety

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RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
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Author Spotlight: Quantification of Aflatoxins and Phytoalexins in Peanut Seeds to Identify Genetic Resistance Against Aspergillus
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Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
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Area of Science:

  • Food Science
  • Toxicology
  • Agricultural Science

Background:

  • Aflatoxin B1 (AFB1) is a highly toxic mycotoxin found in animal feed and human food.
  • AFB1 poses significant risks to agriculture, food safety, animal health, and human health.

Purpose of the Study:

  • To review phytochemicals that resist AFB1.
  • To elucidate the anti-AFB1 mechanisms of these natural compounds.
  • To discuss common characteristics, research shortcomings, and future directions for phytochemicals against AFB1.

Main Methods:

  • Literature review of studies on phytochemicals and AFB1.
  • Analysis of mechanisms including antioxidative, anti-inflammatory, and antiapoptotic pathways.
  • Examination of *in vivo* AFB1 metabolism inhibition by phytochemicals.
phytochemical
toxic mechanism

Main Results:

  • Phytochemicals demonstrate potential in resisting AFB1 due to low toxicity and biocompatibility.
  • Mechanisms of action involve antioxidative, anti-inflammatory, and antiapoptotic effects.
  • Phytochemicals can inhibit AFB1 genotoxicity by influencing its metabolism and promoting elimination.

Conclusions:

  • Phytochemicals offer a promising natural strategy to combat AFB1 toxicity in agriculture and food safety.
  • Further research is needed to address current shortcomings and optimize the application of these compounds.
  • Understanding phytochemical mechanisms can lead to improved food safety and animal/human health outcomes.