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Molecular subtypes of ischemic heart disease based on circadian rhythm

Zhaokai Zhou1,2, Ge Zhang3, Zhan Wang2

  • 1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Scientific Reports
|June 19, 2024
PubMed

Insights

Circadian rhythm disruption (CRD) significantly impacts coronary heart disease (CAD) progression and prognosis. A novel CRD score identifies distinct patterns and offers potential for personalized CAD therapies.

Area of Science:

  • Cardiology
  • Chronobiology
  • Genomics

Background:

  • Coronary atherosclerotic heart disease (CAD) is a leading global chronic illness.
  • Circadian rhythm disruption (CRD) is linked to various disease progressions, but its role in CAD is unclear.

Purpose of the Study:

  • To investigate the association between CRD and CAD development.
  • To establish quantitative markers for CRD in CAD patients.

Main Methods:

  • Utilized a Circadian rhythm disruption score (CRDscore) to quantify CRD levels in CAD samples.
  • Analyzed CRDscore distributions across different CAD subtypes.

Main Results:

  • A high CRDscore was significantly associated with adverse prognosis in CAD patients.
  • CRDscore demonstrated a substantial correlation with CAD progression.
  • Distinct CRDscore distributions were observed among various CAD subtypes.

Conclusions:

  • This study reveals the relationship between CRD and CAD at the single-cell level.
  • Established reliable markers for CAD development, treatment, and prognosis.
  • Suggests potential for circadian rhythm-based therapies in personalized CAD management.

Keywords:
BioinformaticsCircadian rhythmIschemic heart diseaseTranscriptome

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