Predictive capacity for local disease control of neogenin-1 (NEO1) transcriptional expression in patients with head and neck squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Lower neogenin-1 (NEO1) gene expression predicts worse local control in head and neck squamous cell carcinoma (HNSCC) patients. Patients with low NEO1 expression face a significantly higher risk of local tumor recurrence after surgery.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Genetics
Background
- Head and neck squamous cell carcinoma (HNSCC) is a significant global health concern.
- Identifying reliable biomarkers for predicting treatment outcomes in HNSCC is crucial for personalized medicine.
Purpose Of The Study
- To investigate the association between neogenin-1 (NEO1) gene transcriptional expression and local disease control in surgically treated HNSCC patients.
- To determine if NEO1 expression can serve as a predictive marker for local recurrence after surgery.
Main Methods
- Retrospective analysis of tumor biopsies from 107 HNSCC patients.
- Quantification of NEO1 transcriptional expression using reverse transcription-polymerase chain reaction (RT-PCR).
- Recursive partitioning analysis to categorize NEO1 expression levels relative to local disease control.
Main Results
- Lower NEO1 transcriptional expression was significantly associated with poorer local disease control.
- Patients with low NEO1 expression exhibited a 5-year local recurrence-free survival of 61.8% compared to 85.6% for those with high expression (P=0.003).
- Multivariable analysis indicated a 2.7-fold increased risk of local recurrence in patients with lower NEO1 expression (P=0.043).
Conclusions
- Reduced transcriptional expression of the NEO1 gene is a significant predictor of increased local recurrence risk in HNSCC patients post-surgery.
- NEO1 expression levels may offer valuable prognostic information for guiding treatment strategies in HNSCC.
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