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Effectiveness of repetitive transcranial magnetic stimulation for insomnia disorder on fear memory extinction: study
Jingjing Sun1, Bidan Zhang1, Wenyue Xu1
1Zhenjiang Mental Health Center, Zhenjiang, Jiangsu, 212001, China.
Background:
Fear memory extinction is closely related to insomnia. Repetitive transcranial magnetic stimulation (rTMS) is safe and effective for treating insomnia disorder (ID), and it has been shown to be an efficient method for modulating fear extinction. However, whether rTMS can improve fear extinction memory in ID patients remains to be studied. In this study, we specifically aim to (1) show that 1 Hz rTMS stimulation could improve fear extinction memory in ID patients and (2) examine whether changes in sleep mediate this impact.
Methods And Design:
We propose a parallel group randomised controlled trial of 62 ID participants who meet the inclusion criteria. Participants will be assigned to a real rTMS group or a sham rTMS group. The allocation ratio will be 1:1, with 31 subjects in each group. Interventions will be administered five times per week over a 4-week period. The assessments will take place at baseline (week 0), post-intervention (week 4), and 8-week follow-up (week 8). The primary outcome measure of this study will be the mean change in the Pittsburgh Sleep Quality Index (PSQI) scores from baseline to post-intervention at week 4. The secondary outcome measures include the mean change in skin conductance response (SCR), fear expectation during fear extinction, Insomnia Severity Index (ISI), Zung Self-Rating Anxiety Scale (SAS), and the Zung Self-Rating Depression Scale (SDS).
Discussion:
This study will be the first examination of the impact of rTMS on fear memory extinction in ID patients.
Trial Registration:
Chinese Clinical Trials Register ChiCTR2300076097. Registered on 25 September 2021.
