Bias-Free Cardiac Monitoring Capsule.

Area of Science:

• Biomedical Engineering
• Cardiology
• Materials Science

Background:

• Cardiovascular disease (CVD) is a leading global cause of death.
• Early detection of CVDs is challenging due to subtle changes in cardiac contractility.
• Continuous monitoring of cardiac function is crucial for long-term CVD surveillance and early diagnosis.

Purpose of the Study:

• To introduce an implantable, zero-power consumption, bias-free cardiac monitoring capsule (BCMC) for in situ monitoring of cardiac contractility.
• To enhance the BCMC's performance using a nanoparticle self-adsorption method.
• To evaluate the BCMC's capability in detecting cardiac contractility changes and associated CVDs in a preclinical setting.

Main Methods:

• Development of a novel triboelectric effect-based BCMC.
• Utilizing a nanoparticle self-adsorption technique to improve BCMC output performance by over 10 times.
• Implantation of the BCMC into the right ventricle of swine via catheter intervention.
• Wireless transmission of physiological signals to a mobile terminal for analysis.

Main Results:

• The BCMC demonstrated improved output performance through nanoparticle self-adsorption.
• Successful in situ monitoring of cardiac contractility changes in swine.
• Detection of corresponding cardiovascular disease indicators.
• Wireless data transmission for real-time analysis.

Conclusions:

• The developed BCMC offers a promising, zero-power solution for continuous cardiac contractility monitoring.
• This technology facilitates precise monitoring and early diagnosis of cardiovascular diseases.
• The BCMC represents a novel approach for long-term CVD surveillance and management.