Related Experiment Video

Updated: Jun 23, 2025

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells

Published on: July 30, 2020

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An analysis of AURKB's prognostic and immunological roles across various cancers

Jun Li1, Cui Cheng2, Jiajun Zhang1

  • 1Department of Urology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.

Journal of Cellular and Molecular Medicine
|June 20, 2024
PubMed

Insights

Aurora kinase B (AURKB) is highly expressed in most cancers and impacts progression. This study suggests AURKB may serve as a potential biomarker for various cancers, including kidney renal clear cell carcinoma (KIRC).

Area of Science:

  • Molecular biology
  • Cancer research
  • Bioinformatics

Background:

  • Aurora kinase B (AURKB) is crucial for mitosis and implicated in cancer development.
  • The precise mechanisms of AURKB's role in diverse cancers are not fully understood.

Purpose of the Study:

  • To elucidate the multifaceted role of AURKB in various cancer types.
  • To investigate AURKB's association with prognosis, pathological stage, and immune factors.

Main Methods:

  • Utilized bioinformatics to analyze AURKB transcript, protein, promoter methylation, and mutation levels.
  • Examined associations with prognosis, pathological stage, immune infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI).
  • Performed immunohistochemical staining on 50 kidney renal clear cell carcinoma (KIRC) cases.

Main Results:

  • AURKB is highly expressed in most cancers, with varying protein and promoter methylation levels across cancer types.
  • AURKB expression correlates with overall survival in 12 cancers and progression-free survival in 11 cancers.
  • Elevated AURKB levels are linked to advanced stages in 10 cancers and show strong associations with immune infiltration, TMB, and MSI.

Conclusions:

  • AURKB plays a significant role in cancer progression, potentially through cell cycle and immune-related pathways.
  • AURKB protein is highly expressed in KIRC, validating its role in this specific cancer.
  • AURKB emerges as a potential pan-cancer biomarker and a specific biomarker for KIRC.
Keywords:
biomarkercell cycleimmune infiltrationimmunotherapykidney renal clear cell carcinomapan‐cancer

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