Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Next Generation Digital Morphology: Blast Preclassification in Bone Marrow Aspirates.

International journal of laboratory hematology·2026
Same author

Performance of Automated Hematology Analyzer Criteria in Detecting Peripheral Blood Smear Abnormalities: A Systematic Literature Review.

International journal of laboratory hematology·2026
Same author

Practical Considerations in the Implementation of Peripheral Smear Review in the Clinical Laboratory.

International journal of laboratory hematology·2026
Same author

Assessment of the Performance of Siemens Scopio Digital Morphology on Bone Marrow Aspirates in Onco-Hematology.

International journal of laboratory hematology·2026
Same author

ICSH Recommendations for Monocyte Cell Lineage Morphologic Identification, Nomenclature Harmonization, and Utilization as a Biomarker.

International journal of laboratory hematology·2025
Same author

Digital morphology compared to the optical microscope: A validation study on reporting bone marrow aspirates.

International journal of laboratory hematology·2024

Related Experiment Video

Updated: Jun 23, 2025

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

4.1K

Hematological cytomorphology: Where we are.

G Zini1,2

  • 1Catholic University of Sacred Heart Rome, Milan, Italy.

International Journal of Laboratory Hematology
|June 20, 2024
PubMed
Summary

This review traces the history of blood cell morphology observation, from early microscopes to AI-powered digital analysis. Advancements in hematology diagnostics highlight morphology's enduring clinical significance.

Keywords:
general hematologyleukemiamorphology

More Related Videos

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

11.6K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

11.6K

Related Experiment Videos

Last Updated: Jun 23, 2025

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
08:34

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

4.1K
Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

11.6K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

11.6K

Area of Science:

  • Hematology
  • Medical Diagnostics
  • Microscopy

Background:

  • Blood cell morphology has been historically significant, with early observations dating back to Hippocrates and Galeno.
  • The discovery of cells and microscopy advancements by Hooke and van Leeuwenhoek enabled the study of blood cell morphology.
  • Key figures like Hewson, Donné, and Ehrlich contributed to the evolution of hematological understanding.

Purpose of the Study:

  • To provide a comprehensive overview of the historical development of blood cell morphology observation.
  • To highlight key technological advancements and their impact on hematology diagnostics.
  • To underscore the continued clinical relevance of morphology in modern hematology practice.

Main Methods:

  • Historical review of microscopy and diagnostic cytology.
  • Examination of the evolution from manual cell counting to automated hematological systems.
  • Integration of flow cytometry, cytogenetics, molecular techniques, and digital microscopy with AI.

Main Results:

  • Morphological analysis is crucial for predicting disease outcomes and guiding treatment, especially in hematological neoplasms.
  • Automated complete blood counting supports microscopic examination in diagnosing hematological disorders.
  • Digital microscopy and Artificial Intelligence enhance morphological analysis, improving diagnostic efficiency and offering new diagnostic pathways.

Conclusions:

  • The historical evolution of blood cell morphology observation spans centuries, from early microscopes to advanced AI.
  • Technological integration, including AI and digital microscopy, has revolutionized hematology diagnostics.
  • Blood cell morphology remains a cornerstone of modern hematology, vital for accurate diagnosis and prognostication.