The effects of venlafaxine on depressive-like behaviors and gut microbiome in cuprizone-treated mice
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View abstract on PubMed
Summary
This summary is machine-generated.Venlafaxine (Ven) alleviates depressive-like behaviors and normalizes gut microbiota in cuprizone (CPZ)-induced demyelination mouse models. These findings suggest Ven
Area Of Science
- Neuroscience
- Microbiology
- Pharmacology
Background
- Cuprizone (CPZ) induces demyelination, gut dysbiosis, and depressive-like behaviors in mice.
- The impact of venlafaxine (Ven) on the gut microbiome in CPZ-treated mice remains largely unexplored.
Purpose Of The Study
- To investigate the effects of venlafaxine (Ven) on the gut microbiome and depressive-like behaviors in a cuprizone (CPZ)-induced demyelination mouse model.
Main Methods
- Male C57BL/6J mice were administered cuprizone (CPZ) for 5 weeks to induce demyelination.
- Venlafaxine (Ven) or vehicle was administered orally for the last 2 weeks of CPZ treatment.
- Gut microbiota composition and depressive-like behaviors were assessed.
Main Results
- CPZ treatment led to depressive-like behaviors and altered gut microbial diversity and composition.
- Venlafaxine (Ven) treatment alleviated depressive-like behaviors in CPZ-exposed mice.
- Venlafaxine (Ven) modulated gut microbiota, increasing beneficial bacteria like Lactobacillus and Bifidobacterium.
Conclusions
- Venlafaxine (Ven) demonstrates antidepressant-like effects in a demyelination model.
- The antidepressant effects of Venlafaxine (Ven) may be mediated through the regulation of gut microbiota.
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