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Related Concept Videos

Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Next-generation Sequencing03:00

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Genome Annotation and Assembly03:36

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Maxam-Gilbert Sequencing01:05

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Related Experiment Video

Updated: Jun 23, 2025

Novel Sequence Discovery by Subtractive Genomics
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Corrigendum: LocoGSE, a sequence-based genome size estimator for plants.

Pierre Guenzi-Tiberi1, Benjamin Istace1, Inger Greve Alsos2

  • 1Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.

Frontiers in Plant Science
|June 20, 2024
PubMed
Summary

This study corrects the article DOI for a previous publication. The correct DOI is 10.3389/fpls.2024.1328966.

Keywords:
1C1Cxenvironmental DNAgenome sizegenome size estimationgenome-skimmingplant genomicsploidy

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Area of Science:

  • Plant Science
  • Genetics
  • Molecular Biology

Context:

  • Previous publication requires a DOI correction.
  • Ensuring accurate citation and discoverability of scientific literature.

Purpose:

  • To provide the correct Digital Object Identifier (DOI) for the article.
  • To rectify a citation error and maintain academic integrity.

Summary:

  • The article DOI has been updated to 10.3389/fpls.2024.1328966.
  • This correction ensures proper referencing and access to the research.

Impact:

  • Facilitates accurate citation and retrieval of the published research.
  • Improves the reliability of scientific databases and literature searches.