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  1. Home
  3. Effectiveness Of Colorectal Cancer Screening Integrating Non-genetic And Genetic Risk: A Prospective Study Based On Uk Biobank Data.
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  3. Effectiveness Of Colorectal Cancer Screening Integrating Non-genetic And Genetic Risk: A Prospective Study Based On Uk Biobank Data.

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Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on

Yu Zhang1, Chao Sheng1, Zhangyan Lyu1

  • 1Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Key Laboratory of Prevention and Control of Human Major Diseases, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.

Cancer Biology & Medicine
|June 20, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Risk-stratified colorectal cancer (CRC) screening using genetic and non-genetic factors significantly reduces CRC incidence and mortality in intermediate and high-risk individuals. Low-risk individuals did not benefit from screening.

Keywords:
Colorectal cancerincidencemortalitypolygenic risk scorescreening

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Area of Science:

  • Oncology
  • Genetics
  • Public Health

Background:

  • Colorectal cancer (CRC) screening is crucial for early detection and mortality reduction.
  • Integrating non-genetic and genetic risk factors can refine screening strategies.
  • Existing models like QCancer-10 and polygenic risk scores offer potential for risk stratification.

Purpose of the Study:

  • To integrate non-genetic (QCancer-10) and genetic (139-variant polygenic risk score) factors for CRC risk assessment.
  • To evaluate the effectiveness of risk-stratified screening on CRC incidence and mortality.
  • To identify subgroups that benefit most from CRC screening.

Main Methods:

  • Utilized UK Biobank data from 430,908 participants.
  • Calculated 10-year CRC risk using an integrated genetic and non-genetic model.
  • Stratified participants into low-, intermediate-, and high-risk groups.
  • Analyzed screening-associated hazard ratios (HRs) and absolute risk reductions (ARRs).

    • Main Results:

    • CRC incidence and mortality were significantly reduced in screened intermediate- and high-risk groups (approx. 60% of population).
    • Screening showed substantial absolute risk reductions for incidence (0.17-0.43) and mortality (0.08-0.24) in these groups.
    • No significant benefit of screening was observed in the low-risk group.
    • Screening was most effective for men and individuals with distal CRC within higher-risk strata.

    Conclusions:

    • Integrated genetic and non-genetic risk factors enable effective risk-stratified CRC screening.
    • This approach provides evidence for prioritizing screening resources.
    • Findings support personalized screening strategies for optimal CRC prevention and resource allocation.